GSK269962 hydrochloride

  • Chemical Properties
CAS No. 2095432-71-4 Cat. No. BCP26171
Name GSK269962 hydrochloride
Synonyms GSK269962 HCl; GSK269962 hydrochloride; GSK269962; GSK 269962; GSK-269962; GSK269962A; GSK 269962A; GSK-269962A; GSK26996B;
Formula C29H31ClN8O5 M. Wt 607.07
  • Biological Activity
Description GSK269962 is a selective ROCK inhibitor with IC50 values of 1.6 and 6 nM for ROCK-I and ROCK-II, respectively. GSK 269962 could reverse corticosterone-induced depressive-like behaviour and changes in cystometric parameters associated with detrusor overactivity, as well as undo the alterations of several biomarkers related to both disorders (i.e., pro-inflammatory/anti-inflammatory cytokines and neurotrophins) in serum, urinary bladder, and different brain structures.
Pathways Cell Cycle/DNA Damage TGF beta/Smad  Wnt/Stem Cell 
Targets ROCK 

Structure

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