MPI-5a
CAS No. | 1259296-46-2 | Cat. No. | BCP29593 |
Name | MPI-5a | ||
Synonyms | MPI 5a;MPI5a;HDAC6 Inhibitor;Histone Deacetylase 6; | ||
Formula | C16H17N3O3 | M. Wt | 299.32 |
Description | MPI-5a is a potent selective inhibitor of HDAC6, and poorly blocks other HDAC enzymes.HDAC6 is a predominantly cytoplasmic enzyme that targets α-tubulin, cortactin, and heat shock protein 90, as well as other substrates. In this way, it impacts development, proliferation, invasion, and tumorigenesis. HDAC6 Inhibitor is a potent and selective inhibitor of HDAC6 (IC50 = 36 nM) that poorly blocks other HDAC enzymes. It is cell permeable, inhibiting the acetylation of tubulin in cells with an IC50 value of 210 nM. | ||
Pathways | Cell Cycle/DNA Damage Epigenetics | ||
Targets | HDAC |
Structure
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