MPI-5a

  • Chemical Properties
CAS No. 1259296-46-2 Cat. No. BCP29593
Name MPI-5a
Synonyms MPI 5a;MPI5a;HDAC6 Inhibitor;Histone Deacetylase 6;
Formula C16H17N3O3 M. Wt 299.32
  • Biological Activity
Description MPI-5a is a potent selective inhibitor of HDAC6, and poorly blocks other HDAC enzymes.HDAC6 is a predominantly cytoplasmic enzyme that targets α-tubulin, cortactin, and heat shock protein 90, as well as other substrates. In this way, it impacts development, proliferation, invasion, and tumorigenesis. HDAC6 Inhibitor is a potent and selective inhibitor of HDAC6 (IC50 = 36 nM) that poorly blocks other HDAC enzymes. It is cell permeable, inhibiting the acetylation of tubulin in cells with an IC50 value of 210 nM.
Pathways Cell Cycle/DNA Damage Epigenetics 
Targets HDAC 

Structure

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