Tarloxotinib bromide
| CAS No. | 1636180-98-7 | Cat. No. | BCP32560 |
| Name | Tarloxotinib bromide | ||
| Synonyms | PR-610;PR 610;PR610;TH-4000;TH 4000;TH4000; | ||
| Formula | C24H24Br2ClN9O3 | M. Wt | 681.77 |
| Description | Tarloxotinib bromide is a prodrug designed to selectively release a covalent (irreversible) EGFR tyrosine kinase inhibitor under severe hypoxia, a feature of many solid tumors. Tarloxotinib has the potential to effectively shut down aberrant EGFR signaling in a tumor-selective manner, thus potentially avoiding or reducing the systemic side effects associated with currently available EGFR tyrosine kinase inhibitors. | ||
| Pathways | Angiogenesis/Protein Tyrosine Kinase Jak/Stat Pathway | ||
| Targets | EGFR | ||
Structure
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