JBJ-04-125-02
CAS No. | 2060610-53-7 | Cat. No. | BCP32863 |
Name | JBJ-04-125-02 | ||
Synonyms | |||
Formula | C29H26FN5O3S | M. Wt | 543.61 |
Description | JBJ-04-125-02 is a potent, mutant-selective, allosteric and orally active EGFR inhibitor with an IC50 of 0.26 nM for EGFRL858R/T790M. JBJ-04-125-02 can inhibit cancer cell proliferation and EGFRL858R/T790M/C797S signaling. JBJ-04-125-02 has anti-tumor activities. | ||
Pathways | Angiogenesis/Protein Tyrosine Kinase Jak/Stat Pathway | ||
Targets | EGFR |
Structure
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