TC-S 7001
| CAS No. | 867017-68-3 | Cat. No. | BCP34134 |
| Name | TC-S 7001 | ||
| Synonyms | TC S 7001; TCS 7001; TC-S-7001; TCS7001; Azaindole-1; Azaindole 1; ROCK-IN-2; | ||
| Formula | C18H13ClF2N6O | M. Wt | 402.79 |
| Description | TC-S 7001 is a potent and highly selective ROCK inhibitor. Its IC50 values are 0.6 and 1.1 nM for ROCK1 and ROCK2, respectively. It exhibits >200-fold selectivity over TRK and FLT3 receptors, and >900-fold selectivity over a panel of other kinases and cardiovascular relevent enzymes and receptors. It reduces blood pressure in normotensive and hypertensive rats. | ||
| Pathways | Cell Cycle/DNA Damage TGF beta/Smad Wnt/Stem Cell | ||
| Targets | ROCK | ||
Structure
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