Tivozanib
| CAS No. | 475108-18-0 | Cat. No. | BCP01980 |
| Name | Tivozanib | ||
| Synonyms | AV-951;AV951;AV 951; KRN951; KRN 951; KRN-951; | ||
| Formula | C22H19ClN4O5 | M. Wt | 454.86 |
| Description | Tivozanib, also known as KRN951, is an orally bioavailable inhibitor of vascular endothelial growth factor receptors (VEGFRs) 1, 2 and 3 with potential antiangiogenic and antineoplastic activities. Tivozanib binds to and inhibits VEGFRs 1, 2 and 3, which may result in the inhibition of endothelial cell migration and proliferation, inhibition of tumor angiogenesis and tumor cell death. VEGFR tyrosine kinases, frequently overexpressed by a variety of tumor cell types, play a key role in angiogenesis. | ||
| Related Products | 682745-41-1（Tivozanib hydrochloride hydrate） | ||
| Pathways | Angiogenesis/Protein Tyrosine Kinase | ||
| Targets | PDGFR VEGFR | ||
Structure
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