Beclabuvir
| CAS No. | 958002-33-0 | Cat. No. | BCP11013 |
| Name | Beclabuvir | ||
| Synonyms | BMS791325;BMS 791325;BMS-791325; | ||
| Formula | C36H45N5O5S | M. Wt | 659.84 |
| Description | Beclabuvir, also known as BMS-791325, is an allosteric inhibitor that binds to thumb site 1 of the hepatitis C virus (HCV) NS5B RNA-dependent RNA polymerase. BMS-791325 inhibits recombinant NS5B proteins from HCV genotypes 1, 3, 4, and 5 at 50% inhibitory concentrations (IC50) below 28 nM. In cell culture, BMS-791325 inhibited replication of HCV subgenomic replicons representing genotypes 1a and 1b at 50% effective concentrations (EC50s) of 3 nM and 6 nM, respectively, with similar (3 to 18 nM) values for genotypes 3a, 4a, and 5a. B | ||
| Pathways | Protease/Metabolic Enzyme Microbiology/Virology | ||
| Targets | HCV Protease HCV | ||
Structure
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