AF353

  • Chemical Properties
CAS No. 865305-30-2 Cat. No. BCP28391
Name AF353
Synonyms AF-353; AF 353;Ro-4;
Formula C14H17IN4O2 M. Wt 400.21
  • Biological Activity
Description AF353 is a P2X3 receptor antagonist. Antagonism of the P2X3 receptor is one of the potential therapeutic strategies for the management of neuropathic pain because P2X3 receptors are predominantly localized on small to medium diameter C- and Aδ-fiber primary afferent neurons, which are related to the pain-sensing system.
Pathways Ion Channel/Membrane Transporter Neuro Signaling Pathway GPCR/G Protein 
Targets P2 Receptor  

Structure

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