AT9283
| CAS号 | 896466-04-9 | 货号 | BCP11714 |
| 中文名 | AT9283 | ||
| 英文名 | AT9283 | ||
| 中文别名 | |||
| 英文别名 | AT 9283; AT-9283; AT-9283 free base; | ||
| 分子式 | C19H23N7O2 | 分子量 | 381.44 |
| 生物活性 | AT9283 is a multikinase inhibitor, is also a small-molecule inhibitor of several kinases with potential antineoplastic activity. Multikinase inhibitor AT9283 binds to and inhibits Aurora kinases A and B, JAK2 (Janus kinase 2) and the kinase BCR-ABL, which may result in the inhibition of cellular division and proliferation and the induction of apoptosis in tumor cells that overexpress these kinases. Aurora kinases are serine-threonine kinases that play essential roles in mitotic checkpoint control during mitosis; JAK2 is a kinase that transduces signals from the single chain and IL-3 cytokine receptor families, and from the IFN-gamma receptors; BCR-ABL is a fusion protein with tyrosine kinase activity that is commonly found in CML. | ||
| 信号通路 | Angiogenesis/Protein Tyrosine Kinase Cell Cycle/DNA Damage Jak/Stat Pathway Wnt/Stem Cell Epigenetics | ||
| 靶 点 | Src/Bcr Abl Aurora JAK | ||
结构式
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