AT9283

参考资料仅供科学研究，不可用于个人用途。

货号：BCP11714CAS号：896466-04-9纯度：98%

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CAS号	896466-04-9	货号	BCP11714
中文名	AT9283
英文名	AT9283
中文别名
英文别名	AT 9283; AT-9283; AT-9283 free base;
SMILES	O=C(NC1CC1)NC2=CNN=C2C3=NC4=CC=C(C=C4N3)CN5CCOCC5
化学名称
分子式	C19H23N7O2	分子量	381.44
纯度	98%	配送	惯例下常温包邮
产品描述	AT9283 is a multikinase inhibitor, is also a small-molecule inhibitor of several kinases with potential antineoplastic activity. Multikinase inhibitor AT9283 binds to and inhibits Aurora kinases A and B, JAK2 (Janus kinase 2) and the kinase BCR-ABL, which may result in the inhibition of cellular division and proliferation and the induction of apoptosis in tumor cells that overexpress these kinases. Aurora kinases are serine-threonine kinases that play essential roles in mitotic checkpoint control during mitosis; JAK2 is a kinase that transduces signals from the single chain and IL-3 cytokine receptor families, and from the IFN-gamma receptors; BCR-ABL is a fusion protein with tyrosine kinase activity that is commonly found in CML.