LDE225 Diphosphate
| CAS No. | 1218778-77-8 | Cat. No. | BCP11860 |
| Name | LDE225 Diphosphate | ||
| Synonyms | NVP-LDE225; NVP-LDE-225; NVP LDE225;LDE-225;LDE 225;Erismodegib Diphosphate;Sonidegib phosphate; | ||
| Formula | C26H32F3N3O11P2 | M. Wt | 681.49 |
| Description | Sonidegib phosphate, the phosphate of sonidegib, also known as LDE225 or NPV-LDE225. Sonidegib is a Hedgehog signaling pathway inhibitor (via smoothened antagonism) being developed as an anticancer agent by Novartis. It was approved by the FDA for treating basal cell carcinoma in July 2015. It has demonstrated significant efficacy against melanoma in vitro and in vivo. It also demonstrated efficacy in a mouse model of pancreatic cancer. | ||
| Pathways | GPCR/G Protein Wnt/Stem Cell | ||
| Targets | Smoothened/Smo Hedgehog | ||
Structure
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