Choline Fenofibrate

CAS No.	856676-23-8	Cat. No.	BCP28592
Name	Choline Fenofibrate
Synonyms	Fenofibrate de choline;Trilipix;ABT-335; ABT 335; ABT335; HIP0901; HIP-0901; HIP 0901;
Formula	C22H28ClNO5	M. Wt	421.91

Description	Choline fenofibrate, also known as ABT-335 or fenofibric acid, a lipid regulating agent available as delayed release capsules for oral administration. The lipid-modifying effects of fenofibric acid seen in clinical practice have been explained in vivo in transgenic mice and in vitro in human hepatocyte cultures by the activation of peroxisome proliferator activated receptor α (PPARα). Through this mechanism, fenofibric acid increases lipolysis and elimination of triglyceride-rich particles from plasma by activating lipoprotein lipase and reducing production of Apo CIII (an inhibitor of lipoprotein lipase activity). Activation of PPARα also induces an increase in the synthesis of HDL-C and Apo AI and AII.
Pathways	Protease/Metabolic Enzyme Cell Cycle/DNA Damage
Targets	Cytochrome P450 PPAR

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