LM22B-10
| CAS No. | 342777-54-2 | Cat. No. | BCP30139 |
| Name | LM22B-10 | ||
| Synonyms | LM22B 10; LM22B10; LM 22B10; LM-22B10; LM22B10; | ||
| Formula | C27H33ClN2O4 | M. Wt | 485.02 |
| Description | LM22B-10 is a TrkB and TrkC agonist. LM22B-10 exhibits neurotrophic activity (EC50 = 200-300 nM). LM22B-10 improves survival and increases neurite outgrowth in hippocampal cells in vitro. LM22B-10 increased cell survival and strongly accelerated neurite outgrowth, superseding the effects of brain-derived neurotrophic factor (BDNF), NT-3 or the two combined. | ||
| Pathways | Angiogenesis/Protein Tyrosine Kinase PI3K/Akt/mTOR MAPK Pathway | ||
| Targets | Trk Receptor MEK/ERK AKT | ||
Structure
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