PTC299

  • Chemical Properties
CAS No. 1256565-36-2 Cat. No. BCP32869
Name PTC299
Synonyms PTC-299;PTC 299;
Formula C25H20Cl2N2O3 M. Wt 467.34
  • Biological Activity
Description PTC299 is a potent, orally bioavailable VEGFA inhibitor, targets dihydroorotate dehydrogenase (DHODH), resulting in cell growth inhibition and differentiation in leukemias, including acute myeloid leukemia, linking DHODH regulation and stress-induced VEGFA and angiogenesis.
Pathways Angiogenesis/Protein Tyrosine Kinase Cell Cycle/DNA Damage 
Targets DNA/RNA Synthesis VEGFR 

Structure

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