A 438079 Hydrochloride
| CAS号 | 899507-36-9 | 货号 | BCP34027 |
| 中文名 | A 438079 Hydrochloride | ||
| 英文名 | A 438079 Hydrochloride | ||
| 中文别名 | |||
| 英文别名 | A-438079 HCl;A438079 hydrochloride; | ||
| 分子式 | C13H10Cl3N5 | 分子量 | 342.61 |
| 生物活性 | A-438079 is a P2X7 receptor antagonist. A438079 protects against acetaminophen-induced liver injury by inhibiting p450 isoenzymes, not by inflammasome activation. A-438079 partially but significantly prevented the 6-OHDA-induced depletion of striatal DA stores. P2X7R inhibitor A-438079 reduced electrographic and clinical seizure severity during status epilepticus and reduced seizure-induced neuronal death in the neocortex. Blockade of P2X(7) receptors may represent a novel protective strategy for striatal DA terminals in Parkinson's disease. | ||
| 信号通路 | Ion Channel/Membrane Transporter Neuro Signaling Pathway GPCR/G Protein | ||
| 靶 点 | P2 Receptor | ||
结构式
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