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| CAS号 | 899507-36-9 | 货号 | BCP34027 |
| 中文名 | A 438079 Hydrochloride | ||
| 英文名 | A 438079 Hydrochloride | ||
| 中文别名 | |||
| 英文别名 | A-438079 HCl;A438079 hydrochloride; | ||
| SMILES | C1=CC(=C(C(=C1)Cl)Cl)C2=NN=NN2CC3=CN=CC=C3.Cl | ||
| 化学名称 | |||
| 分子式 | C13H10Cl3N5 | 分子量 | 342.61 |
| 纯度 | 98% | 配送 | 惯例下常温包邮 |
| 产品描述 | A-438079 is a P2X7 receptor antagonist. A438079 protects against acetaminophen-induced liver injury by inhibiting p450 isoenzymes, not by inflammasome activation. A-438079 partially but significantly prevented the 6-OHDA-induced depletion of striatal DA stores. P2X7R inhibitor A-438079 reduced electrographic and clinical seizure severity during status epilepticus and reduced seizure-induced neuronal death in the neocortex. Blockade of P2X(7) receptors may represent a novel protective strategy for striatal DA terminals in Parkinson's disease. | ||
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