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| CAS号 | 927887-18-1 | 货号 | BCP24140 |
| 中文名 | AF-353 hydrochloride | ||
| 英文名 | AF-353 hydrochloride | ||
| 中文别名 | |||
| 英文别名 | Ro 4 hydrochloride;AF353 HCl; | ||
| SMILES | CC(C)C1=CC(=C(C=C1OC2=CN=C(N=C2N)N)I)OC.Cl | ||
| 化学名称 | |||
| 分子式 | C14H18ClIN4O2 | 分子量 | 436.68 |
| 纯度 | 98% | 配送 | 惯例下常温包邮 |
| 产品描述 | AF-353 is a noncompetitive dual antagonist of the purinoreceptors P2X3 and P2X2/3 (IC50s = 10 and 79.4 nM, respectively). It is selective for P2X3 and P2X2/3 over P2X1, P2X2, P2X4, P2X5, and P2X7 (IC50 = >10 µM for all). It inhibits calcium flux in CHO-K1 cells expressing the rat P2X3 receptor and in 1321N1 cells expressing the human P2X3 and P2X2/3 receptors (IC50s = 8.91, 8.71, and 38.9 nM, respectively). AF-353 decreases the electrical signals in the detrusor, but not striated, muscle of the bladder in female rats. | ||
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