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| CAS号 | 2097117-06-9 | 货号 | BCP44190 |
| 中文名 | Lu AF27139 | ||
| 英文名 | Lu AF27139 | ||
| 中文别名 | |||
| 英文别名 | LuAF27139; Lu-AF27139; | ||
| SMILES | ClC1=CC=C([C@H](N2CCOCC2)CN([H])C(C3=C(C(F)(F)F)N=C(C4=NC=CC=N4)S3)=O)C=C1 | ||
| 化学名称 | |||
| 分子式 | C21H19ClF3N5O2S | 分子量 | 497.92 |
| 纯度 | 98% | 配送 | 惯例下常温包邮 |
| 产品描述 | Lu AF27139 is a novel rodent-active and CNS penetrant P2X7 receptor antagonist. Lu AF27139 is highly selective and potent against rat, mouse, and human forms of the receptors. The rat pharmacokinetic profile is favorable with high oral bioavailability, modest clearance (0.79 L/(h kg)), and good CNS permeability. Lu AF27139 will be a valuable tool for probing the role of the P2X7 receptor in rodent models of CNS diseases. | ||
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