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| CAS号 | 1627900-42-8 | 货号 | BCP44118 |
| 中文名 | JNJ-54166060 | ||
| 英文名 | JNJ-54166060 | ||
| 中文别名 | |||
| 英文别名 | JNJ 54166060; JNJ54166060; | ||
| SMILES | ClC1=C(C(N2CCC(N(C3=CC=C(F)C=N3)C=N4)=C4[C@H]2C)=O)C=CC=C1C(F)(F)F | ||
| 化学名称 | |||
| 分子式 | C20H15ClF4N4O | 分子量 | 438.81 |
| 纯度 | 98% | 配送 | 惯例下常温包邮 |
| 产品描述 | JNJ-54166060 is a potent P2X7 antagonist. Bioactivity data of JNJ-54166060: rP2X7 IC50=4 nM; rP2X7 IC50=115nM; HLM/RLM = 0.35/0.64, ED50 = 2.3 mg/kg in rats. JNJ-54166060 shows high oral bioavailability and low-moderate clearance in preclinical species, acceptable safety margins in rats, and a predicted human dose of 120 mg of QD. Additionally, JNJ-54166060 possesses a unique CYP profile and was found to be a regioselective inhibitor of midazolam CYP3A metabolism. | ||
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