(S)-PF-04995274
| CAS No. | 2170558-28-6 | Cat. No. | BCP37093 |
| Name | (S)-PF-04995274 | ||
| Synonyms | S- PF 04995274;PF 04995274;PF-04995274;PF04995274; | ||
| Formula | C23H32N2O6 | M. Wt | 432.52 |
| Description | PF-04995274 is a potent, high-affinity, orally active and partial serotonin 4 receptor (5-HT4R) agonist. PF-04995274 has an EC50 range of 0.26-0.47 nM for human 5-HT4A/4B/4D/4E (Ki range of 0.15-0.46 nM), and has an EC50 range of 0.59-0.65 nM for rat 5-HT4S/4L/4E (Ki of 0.30 nM for rat 5-HT4S). PF-04995274 is brain penetrant and can be used for cognitive disorders associated with Alzheimer's disease. | ||
| Pathways | Neuro Signaling Pathway GPCR/G Protein | ||
| Targets | 5 HT Receptor/Serotonin Receptor | ||
Structure
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