ASN007
| CAS No. | 2055597-12-9 | Cat. No. | BCP48479 |
| Name | ASN007 | ||
| Synonyms | ASN-007; ASN 007;Erk-IN-3; | ||
| Formula | C22H25ClFN7O2 | M. Wt | 473.93 |
| Description | ASN007, a novel oral ERK inhibitor, shows robust antitumor activity in RAS mutant cancer models. with low single-digit nM IC50 values. ASN007 showed a slow dissociation rate (long target residence time) as compared to several other known ERK inhibitors. In mechanistic cell-based assays, ASN007 inhibited the phosphorylation of ERK1/2 substrates such as RSK1, FRA1, and Elk1 in various cell lines. ASN007 showed single-digit nanomolar antiproliferative activity that was selective for MAPK-pathway dependent cancer cell lines. | ||
| Related Products | 2055597-39-0（ASN007 benzenesulfonate） | ||
| Pathways | MAPK Pathway | ||
| Targets | MEK/ERK | ||
Structure
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