ASN007 benzenesulfonate New
Data Sheet
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| CAS No. | 2055597-39-0 | Cat. No. | BCP48484 |
| Related Products | 2055597-12-9（ASN007） | ||
| Name | ASN007 benzenesulfonate | ||
| Synonyms | ASN-007 benzenesulfonate ;ASN 007 benzenesulfonate ;ERK-IN-3 benzenesulfonate; | ||
| SMILES | |||
| Chemical Name | |||
| Formula | C28H31ClFN7O5S | M. Wt | 632.11 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | ASN007, a novel oral ERK inhibitor, shows robust antitumor activity in RAS mutant cancer models. with low single-digit nM IC50 values. ASN007 showed a slow dissociation rate (long target residence time) as compared to several other known ERK inhibitors. In mechanistic cell-based assays, ASN007 inhibited the phosphorylation of ERK1/2 substrates such as RSK1, FRA1, and Elk1 in various cell lines. ASN007 showed single-digit nanomolar antiproliferative activity that was selective for MAPK-pathway dependent cancer cell lines. | ||
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