Selumetinib sulfate New
Data Sheet
For research use only. Not for human use.
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| CAS No. | 943332-08-9 | Cat. No. | BCP36547 |
| Name | Selumetinib sulfate | ||
| Synonyms | AZD-6244 sulfate;AZD 6244 sulfate;AZD6244 sulfate; ARRY-142886 sulfate; | ||
| SMILES | CN1C=NC2=C1C=C(C(=C2F)NC3=C(C=C(C=C3)Br)Cl)C(=O)NOCCO.OS(=O)(=O)O | ||
| Chemical Name | |||
| Formula | C17H17BrClFN4O7S | M. Wt | 555.76 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | Selumetinib Sulfate is the sulfate salt of selumetinib, an orally active, small molecule with potential antineoplastic activity. Selumetinib is an ATP-independent inhibitor of mitogen-activated protein kinase kinase (MEK or MAPK/ERK kinase) 1 and 2. MEK 1 and 2 are dual specificity kinases that are essential mediators in the activation of the RAS/RAF/MEK/ERK pathway, are often upregulated in various cancer cells, and are drivers of diverse cellular responses, including proliferation. Inhibition of both MEK1 and 2 by selumetinib prevents the activation of MEK1/2 dependent effector proteins and transcription factors, thereby leading to an inhibition of cellular proliferation in various cancers. | ||
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