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APS-2-79 Chemical Structure

APS-2-79

Data Sheet For research use only. Not for human use.
Cat. No. :BCP24938CAS No. :2002381-25-9Purity:98%
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  • Chemical Properties&Biological Activity
CAS No. 2002381-25-9 Cat. No. BCP24938
Name APS-2-79
Synonyms APS 2-79; APS2-79; APS-279; APS 279; APS279;
SMILES CC1=C(C=CC(=C1)OC2=CC=CC=C2)NC3=NC=NC4=CC(=C(C=C43)OC)OC
Chemical Name
Formula C23H21N3O3 M. Wt 387.43
Purity 98% Storage Store at 4-8°C
Description APS-2-79 is a KSR-dependent MAPK modulator. APS-2-79 modulates KSR-dependent MAPK signalling by antagonizing RAF heterodimerization as well as the conformational changes required for phosphorylation and activation of KSR-bound MEK (mitogen-activated protein kinase kinase). APS-2-79 increased the potency of several MEK inhibitors specifically within Ras-mutant cell lines by antagonizing release of negative feedback signalling, demonstrating the potential of targeting KSR to improve the efficacy of current MAPK inhibitors. Co-targeting of enzymatic and scaffolding activities within Ras-MAPK signalling complexes is a therapeutic strategy for overcoming Ras-driven cancers.
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