ONC-201 Dihydrochloride New
Data Sheet
For research use only. Not for human use.
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| CAS No. | 1638178-82-1 | Cat. No. | BCP46830 |
| Related Products | 1616632-77-9（ONC201） 41276-02-2（TIC10 Analogue） | ||
| Name | ONC-201 Dihydrochloride | ||
| Synonyms | ONC201 2HCl;ONC 201 2HCl;ONC-201 2HCl; | ||
| SMILES | CC1=CC=CC=C1CN2C(=O)C3=C(CCN(C3)CC4=CC=CC=C4)N5C2=NCC5.Cl.Cl | ||
| Chemical Name | |||
| Formula | C24H28Cl2N4O | M. Wt | 459.42 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | ONC-201, also known as TIC10, is a potent, orally active, and stable small molecule that transcriptionally induces TRAIL in a p53-independent manner and crosses the blood-brain barrier. TIC10 induces a sustained up-regulation of TRAIL in tumors and normal cells that may contribute to the demonstrable antitumor activity of TIC10. TIC10 inactivates kinases Akt and extracellular signal-regulated kinase (ERK), leading to the translocation of Foxo3a into the nucleus, where it binds to the TRAIL promoter to up-regulate gene transcription. TIC10 is an efficacious antitumor therapeutic agent that acts on tumor cells and their microenvironment to enhance the concentrations of the endogenous tumor suppressor TRAIL. | ||
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