Zinostatin

CAS No.	9014-02-2	Cat. No.	BCP48970
Name	Zinostatin
Synonyms	Neocarzinostatin; Vinostatin;
Formula	C35H35NO12	M. Wt	661.66

Description	Zinostatin is an enediyne antineoplastic antibiotic hybrid containing an aminoglycoside chromophore. Zinostatin is isolated from the bacterium Streptomyces carzinostaticus. The aminoglycoside component of zinostatin intercalates into DNA and the benzene diradical intermediate of the enediyne core binds to the minor groove of DNA, resulting in single- and double-strand breaks in DNA and apoptosis.
Pathways	Cell Cycle/DNA Damage Microbiology/Virology
Targets	DNA/RNA Synthesis Antibiotic

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