NAS-181 methanesulfonate
| CAS No. | 205242-62-2 | Cat. No. | BCP49052 |
| Name | NAS-181 methanesulfonate | ||
| Synonyms | NAS 181 methanesulfonate; NAS181 methanesulfonate; | ||
| Formula | C21H34N2O10S2 | M. Wt | 538.63 |
| Description | NAS-181 methanesulfonate is a 5-HT(1B) receptor antagonist.NAS181 is a potent and selective antagonist of rat 5-HT1B receptor, with a Ki of 47 nM. NAS181 shows 13-fold selectivity for r5-HT1B over bovine 5-HT1B receptor (Ki=630 nM). NAS181 increases the 5-HT turnover and the synaptic concentration of 5-HT by inhibiting terminal r5-HT1B autoreceptors. | ||
| Pathways | Neuro Signaling Pathway GPCR/G Protein | ||
| Targets | 5 HT Receptor/Serotonin Receptor | ||
Structure
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