NAS-181 methanesulfonate New
Data Sheet
For research use only. Not for human use.
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| CAS No. | 205242-62-2 | Cat. No. | BCP49052 |
| Name | NAS-181 methanesulfonate | ||
| Synonyms | NAS 181 methanesulfonate; NAS181 methanesulfonate; | ||
| SMILES | CS(=O)(=O)O.CS(=O)(=O)O.C1COC(CN1)COC2=CC=CC3=C2OCC(=C3)CN4CCOCC4 | ||
| Chemical Name | |||
| Formula | C21H34N2O10S2 | M. Wt | 538.63 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | NAS-181 methanesulfonate is a 5-HT(1B) receptor antagonist.NAS181 is a potent and selective antagonist of rat 5-HT1B receptor, with a Ki of 47 nM. NAS181 shows 13-fold selectivity for r5-HT1B over bovine 5-HT1B receptor (Ki=630 nM). NAS181 increases the 5-HT turnover and the synaptic concentration of 5-HT by inhibiting terminal r5-HT1B autoreceptors. | ||
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