Dactolisib
| CAS No. | 915019-65-7 | Cat. No. | BCP00216 |
| Name | Dactolisib | ||
| Synonyms | NVP-BEZ 235; BEZ-235; BEZ 235; NVP-BEZ235;BEZ235; NVPBEZ235; NVP-BEZ-235; | ||
| Formula | C30H23N5O | M. Wt | 469.54 |
| Description | Dactolisib, also known as BEZ235, is an orally bioavailable phosphatidylinositol 3-kinase (PI3K) inhibitor with potential antineoplastic activity. PI3K inhibitor BEZ235 specifically inhibits PIK3 in the PI3K/AKT kinase (or protein kinase B) signaling pathway, which may trigger the translocation of cytosolic Bax to the mitochondrial outer membrane, increasing mitochondrial membrane permeability; apoptotic cell death may ensue. Bax is a member of the proapoptotic Bcl2 family of proteins. | ||
| Pathways | PI3K/Akt/mTOR | ||
| Targets | PI3K mTOR | ||
Structure
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