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Dactolisib Chemical Structure

Dactolisib

Data Sheet For research use only. Not for human use.
Cat. No. :BCP00216CAS No. :915019-65-7Purity:98%
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  • Chemical Properties&Biological Activity
CAS No. 915019-65-7 Cat. No. BCP00216
Name Dactolisib
Synonyms NVP-BEZ 235; BEZ-235; BEZ 235; NVP-BEZ235;BEZ235; NVPBEZ235; NVP-BEZ-235;
SMILES CC(C1=CC=C(N(C2=C3C=NC4=CC=C(C5=CC6=CC=CC=C6N=C5)C=C24)C(N3C)=O)C=C1)(C)C#N
Chemical Name
Formula C30H23N5O M. Wt 469.54
Purity 98% Storage Store at 4-8°C
Description Dactolisib, also known as BEZ235, is an orally bioavailable phosphatidylinositol 3-kinase (PI3K) inhibitor with potential antineoplastic activity. PI3K inhibitor BEZ235 specifically inhibits PIK3 in the PI3K/AKT kinase (or protein kinase B) signaling pathway, which may trigger the translocation of cytosolic Bax to the mitochondrial outer membrane, increasing mitochondrial membrane permeability; apoptotic cell death may ensue. Bax is a member of the proapoptotic Bcl2 family of proteins.
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