Pazopanib

  • Chemical Properties
CAS No. 444731-52-6 Cat. No. BCP01839
Name Pazopanib
Synonyms GW 786034;GW-786034;GW786034;
Formula C21H23N7O2S M. Wt 437.53
  • Biological Activity
Description Pazopanib potently inhibits VEGF-induced phosphorylation of VEGFR2 in HUVEC cells with IC50 of 8 nM.PPazopanib shows dose-dependent growth inhibition in all synovial sarcoma cell lines including SYO-1 and HS-SY-II cells. Proliferation of SYO-1 and HS-SY-II cells is inhibited even at 1?μg/mL of Pazopanib and is completely abolished at 5?μg/mL. Pazopanib induces G1 arrest, and thereby suppresses the growth of synovial sarcoma cells. Phosphorylation of Akts, GSK-3β, JNKs, p70 S6 Kinase, and mTOR is suppressed in Pazopanib-treated SYO-1 cells compared with that in the vehicle-treated cells. Pazopanib between 20 m g/mL and 22.5 m g/mL shows an increasing reduction of RPE cell viability.
Related Products 635702-64-6(Pazopanib HCl)
Pathways Angiogenesis/Protein Tyrosine Kinase 
Targets PDGFR VEGFR c Kit cFMS FGFR 

Structure

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