Pazopanib HCl

CAS No.	635702-64-6	Cat. No.	BCP02203
Name	Pazopanib HCl
Synonyms	Pazopanib hydrochloride;GW786034 HCl;GW-786034 HCl;GW 786034 HCl;
Formula	C21H23N7O2S.HCl	M. Wt	473.98

Description	Pazopanib potently inhibits VEGF-induced phosphorylation of VEGFR2 in HUVEC cells with IC50 of 8 nM.PPazopanib shows dose-dependent growth inhibition in all synovial sarcoma cell lines including SYO-1 and HS-SY-II cells. Proliferation of SYO-1 and HS-SY-II cells is inhibited even at 1?μg/mL of Pazopanib and is completely abolished at 5?μg/mL. Pazopanib induces G1 arrest, and thereby suppresses the growth of synovial sarcoma cells. Phosphorylation of Akts, GSK-3β, JNKs, p70 S6 Kinase, and mTOR is suppressed in Pazopanib-treated SYO-1 cells compared with that in the vehicle-treated cells.Pazopanib between 20 m g/mL and 22.5 m g/mL shows an increasing reduction of RPE cell viability.
Related Products	444731-52-6（Pazopanib）
Pathways	Angiogenesis/Protein Tyrosine Kinase
Targets	PDGFR VEGFR c Kit cFMS FGFR

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