Canagliflozin
| CAS No. | 842133-18-0 | Cat. No. | BCP02520 |
| Name | Canagliflozin | ||
| Synonyms | JNJ 24831754; JNJ24831754; JNJ-24831754; JNJ24831754AAA; JNJ24831754ZAE; TA 7284; TA-7284; TA7284; | ||
| Formula | C24H25FO5S | M. Wt | 444.52 |
| Description | Canagliflozin inhibits Na+-dependent 14C-AMG uptake in a concentration-dependent fashion. Canagliflozin inhibits 14C-AMG uptake in CHO-hSGLT1 and mSGLT1 cells with IC50 of 0.7 μM and >1 μM, respectively. Canagliflozin inhibits the facilitative (non-Na+-linked) GLUT-mediated 2H-2-DG uptake in L6 myoblasts by less than 50%. In sham-injected oocytes, Canagliflozin (10 μM) or phlorizin (3 mM) alone in the presence of 50 μM DNJ does not affect currents. In SGLT3-injected oocytes, DMSO and Canagliflozin 10 μM inhibits DNJ-induced currents by 15.6% and 23.4%, respectively. | ||
| Pathways | Ion Channel/Membrane Transporter GPCR/G Protein | ||
| Targets | SGLT | ||
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Intragastric and atomized administration of canagliflozin inhibit inflammatory cytokine storm in lipopolysaccharide-treated sepsis in mice: A potential COVID-19 treatment
Publications Citing of Biochempartner's Canagliflozin(CAS:842133-18-0) |
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Canagliflozin Ameliorates NLRP3 Inflammasome-Mediated Inflammation Through Inhibiting NF-κB Signaling and Upregulating Bif-1
Publications Citing of Biochempartner's Canagliflozin(CAS:842133-18-0) |
Structure
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