GSK 269962 trihydrochloride

CAS No.	925213-80-5	Cat. No.	BCP26170
Name	GSK 269962 trihydrochloride
Synonyms	GSK269962 3HCl; GSK269962 trihydrochloride; GSK269962; GSK 269962; GSK-269962; GSK269962A; GSK 269962A; GSK-269962A; GSK26996B;
Formula	C29H33Cl3N8O5	M. Wt	679.98

Description	GSK269962 is a selective ROCK inhibitor with IC50 values of 1.6 and 6 nM for ROCK-I and ROCK-II, respectively. GSK 269962 could reverse corticosterone-induced depressive-like behaviour and changes in cystometric parameters associated with detrusor overactivity, as well as undo the alterations of several biomarkers related to both disorders (i.e., pro-inflammatory/anti-inflammatory cytokines and neurotrophins) in serum, urinary bladder, and different brain structures.
Pathways	Cell Cycle/DNA Damage TGF beta/Smad Wnt/Stem Cell
Targets	ROCK

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