MZ 1
| CAS No. | 1797406-69-9 | Cat. No. | BCP31482 |
| Name | MZ 1 | ||
| Synonyms | MZ1; MZ-1; | ||
| Formula | C49H60ClN9O8S2 | M. Wt | 1002.64 |
| Description | MZ1 is a cell penetrant Proteolysis Targeting Chimera (PROTAC) compound based on (+)-JQ1 conjugated to a von Hippel-Lindau (VHL) ligand. Retains high affinity for BRD2, BRD3 and BRD4 bromodomains (Kd = 13-60 nM) but induces preferential degradation of BRD4 over BRD2 and BRD3 (DC50 values for degradation of BRD4 are 8 and 23 nM in H661 and H838 cells, respectively). Exhibits potent cytotoxicity and antiproliferative effects in AML cell lines (pEC50 = 7.6 in Mv4-11 cells). Negative control cis MZ 1 also available. | ||
| Pathways | Others Pathway Epigenetics | ||
| Targets | Epigenetic Reader Domain PROTAC | ||
Structure
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