GMB-475
| CAS No. | 2490599-18-1 | Cat. No. | BCP31499 |
| Name | GMB-475 | ||
| Synonyms | GMB 475;GMB475;2489876-37-9; | ||
| Formula | C43H46F3N7O7S | M. Wt | 861.93 |
| Description | GMB-475 is a degrader of BCR-ABL1 tyrosine kinase based on PROTAC, overcoming BCR-ABL1-dependent drug resistance. GMB-475 targets BCR-ABL1 protein and recruits the E3 ligase Von Hippel Lindau (VHL), resulting in ubiquitination and subsequent degradation of the oncogenic fusion protein. | ||
| Pathways | Angiogenesis/Protein Tyrosine Kinase Others Pathway | ||
| Targets | Src/Bcr Abl PROTAC | ||
Structure
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