GMB-475 New
Data Sheet
For research use only. Not for human use.
| Size | Price | Stock | Quotation Inquiry |
|---|---|---|---|
| 5.00 mg | Get quote | In-stock | Quotation Inquiry |
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| CAS No. | 2490599-18-1 | Cat. No. | BCP31499 |
| Name | GMB-475 | ||
| Synonyms | GMB 475;GMB475;2489876-37-9; | ||
| SMILES | CC1=C(SC=N1)C2=CC=C(C=C2)CNC(=O)C3CC(CN3C(=O)C(C(C)(C)C)NC(=O)COCCOC4=CC=C(C=C4)C5=CC(=NC=N5)NC6=CC=C(C=C6)OC(F)(F)F)O | ||
| Chemical Name | |||
| Formula | C43H46F3N7O7S | M. Wt | 861.93 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | GMB-475 is a degrader of BCR-ABL1 tyrosine kinase based on PROTAC, overcoming BCR-ABL1-dependent drug resistance. GMB-475 targets BCR-ABL1 protein and recruits the E3 ligase Von Hippel Lindau (VHL), resulting in ubiquitination and subsequent degradation of the oncogenic fusion protein. | ||
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