AU-15330
| CAS No. | 2380274-50-8 | Cat. No. | BCP46987 |
| Name | AU-15330 | ||
| Synonyms | AU 15330; AU15330; | ||
| Formula | C39H49N9O5S | M. Wt | 755.94 |
| Description | AU-15330 is a novel, highly specific and VHL-dependent PROTAC degrader of SWI/SNF ATPase components (SMARCA2, SMARCA4 and PBRM1) that shows preferential cytotoxicity in enhancer-binding transcription factor-addicted cancers at low nanomolar concentrations. AU-15330 induces potent inhibition of tumour growth in xenograft models of prostate cancer and synergizes with the AR antagonist enzalutamide, even inducing disease remission in castration-resistant prostate cancer (CRPC) models without toxicity. | ||
| Pathways | Others Pathway Epigenetics | ||
| Targets | Epigenetic Reader Domain PROTAC | ||
Structure
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