H-1152 Dihydrochloride
| CAS No. | 871543-07-6 | Cat. No. | BCP25257 |
| Name | H-1152 Dihydrochloride | ||
| Synonyms | H-1152 2HCl; H1152 dihydrochloride; | ||
| Formula | C16H23Cl2N3O2S | M. Wt | 392.34 |
| Description | H 1152 dihydrochloride is a rho-kinase (ROCK) inhibitor that displays high selectivity over other protein kinases (IC50 values are 0.012, 0.180, 0.360, 0.745, 3.03, 5.68 and 28.3 μM for ROCKII, CAMKII, PKG, Aurora A, PKA, PKC and MLCK respectively). Inhibits sulprostone-induced contractions in guinea pig aorta (IC50 = 190 nM) and displays proerectile effects in rats. | ||
| Pathways | Cell Cycle/DNA Damage TGF beta/Smad Wnt/Stem Cell | ||
| Targets | ROCK | ||
Structure
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