BGT226
| CAS No. | 915020-55-2 | Cat. No. | BCP26216 |
| Name | BGT226 | ||
| Synonyms | BGT 226; BGT-226; NVP-BGT226; NVP-BGT-226; NVP-BGT 226; | ||
| Formula | C28H25F3N6O2 | M. Wt | 534.54 |
| Description | BGT226 is a phosphatidylinositol 3-kinase (PI3K) inhibitor with potential antineoplastic activity. PI3K inhibitor BGT226 specifically inhibits PIK3 in the PI3K/AKT kinase (or protein kinase B) signaling pathway, which may trigger the translocation of cytosolic Bax to the mitochondrial outer membrane, increasing mitochondrial membrane permeability; apoptotic cell death may ensue. Bax is a member of the proapoptotic Bcl2 family of proteins. | ||
| Pathways | Others Pathway PI3K/Akt/mTOR | ||
| Targets | Autophagy PI3K mTOR | ||
Structure
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