UCN-01

CAS No.	112953-11-4	Cat. No.	BCP14345
Name	UCN-01
Synonyms	UCN 01;UCN01;Staurosporine 7hydroxystaurosporine; KW2401; KW-2401; KW 2401;KRX-0601;KRX0601;KRX 0601;
Formula	C28H26N4O4	M. Wt	482.54

Description	UCN-01, also known as KRX-0601, is a synthetic derivative of staurosporine with antineoplastic activity. 7-hydroxystaurosporine inhibits many phosphokinases, including the serine/threonine kinase AKT, calcium-dependent protein kinase C, and cyclin-dependent kinases. This agent arrests tumor cells in the G1/S of the cell cycle and prevents nucleotide excision repair by inhibiting the G2 checkpoint kinase chk1, resulting in apoptosis. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus).
Pathways	TGF beta/Smad PI3K/Akt/mTOR Epigenetics
Targets	PKC AKT PDK

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