ONO7475
| CAS No. | 1646839-59-9 | Cat. No. | BCP33232 |
| Name | ONO7475 | ||
| Synonyms | ONO-7475; ONO 7475; | ||
| Formula | C32H26N4O6 | M. Wt | 562.58 |
| Description | ONO-7475 is a potent, selective, and orally active novel Anexelekto/MER tyrosine kinase inhibitor with IC50 values of 0.7 nM and 1.0 nM, respectively. ONO-7475 sensitizes AXL-overexpressing EGFR-mutant NSCLC cells to the EGFR-TKIs, suppresses the emergence and maintenance of tolerant cells. ONO-7475 combines with Osimertinib (HY-15772) provides a bright promise for the study of EGFR-mutated non-small cell lung cancer (NSCLC). | ||
| Pathways | Angiogenesis/Protein Tyrosine Kinase Jak/Stat Pathway | ||
| Targets | TAM Receptor Trk Receptor EGFR | ||
Structure
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