G5-7
| CAS No. | 939681-36-4 | Cat. No. | BCP46781 |
| Name | G5-7 | ||
| Synonyms | JAK2 inhibitor G5-7; | ||
| Formula | C22H19F2NO3 | M. Wt | 383.39 |
| Description | G5-7, an orally active and allosteric JAK2 inhibitor, selectively inhibits JAK2 mediated phosphorylation and activation of EGFR (Tyr1068) and STAT3 by binding to JAK2. G5-7 induces cell cycle arrest, apoptosis and possesses antiangiogenic effect. | ||
| Pathways | Angiogenesis/Protein Tyrosine Kinase Jak/Stat Pathway Wnt/Stem Cell Epigenetics | ||
| Targets | JAK | ||
Structure
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