(Z)-Guggulsterone
| CAS No. | 39025-23-5 | Cat. No. | BCP07472 |
| Name | (Z)-Guggulsterone | ||
| Synonyms | Z-Guggulsterone;Guggulsterone Z; | ||
| Formula | C21H28O2 | M. Wt | 312.45 |
| Description | Broad spectrum steroid receptor ligand; mineralocorticoid, progesterone and glucocorticoid receptor antagonist (Ki values are 37, 224 and 252 nM respectively) and weak androgen receptor agonist (Ki = 315 nM). Induces apoptosis in prostate cancer cells and inhibits angiogenesis via suppression of the VEGF-VEGFR2-Akt signaling pathway. Exhibits antilipidemic activity via antagonism of the farnesoid X receptor (FXR) and displays antiseptic, antirheumatic and anti-inflammatory activity in vivo. | ||
| Pathways | Angiogenesis/Protein Tyrosine Kinase Protease/Metabolic Enzyme PI3K/Akt/mTOR | ||
| Targets | VEGFR FXR AKT | ||
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Theabrownin from Pu-erh tea attenuates hypercholesterolemia via modulation of gut microbiota and bile acid metabolism
Publications Citing of Biochempartner's (Z)-Guggulsterone(CAS:39025-23-5) |
Structure
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