ZM 449829
| CAS No. | 4452-06-6 | Cat. No. | BCP07020 |
| Name | ZM 449829 | ||
| Synonyms | ZM449829; ZM-449829; JAK3 Inhibitor V; | ||
| Formula | C13H10O | M. Wt | 182.22 |
| Description | Potent, selective inhibitor of Janus tyrosine kinase 3 (JAK3) which binds competitively to the JAK3 ATP site. pIC50 values are 6.8, 5.0, 4.7, and < 5.0 for JAK3, EGFR, JAK1 and CDK4 respectively. Inhibits STAT-5 phosphorylation and T-cell proliferation. | ||
| Pathways | Angiogenesis/Protein Tyrosine Kinase Jak/Stat Pathway Wnt/Stem Cell Epigenetics | ||
| Targets | JAK | ||
Structure
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