ZM 449829
Data Sheet
For research use only. Not for human use.
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| CAS No. | 4452-06-6 | Cat. No. | BCP07020 |
| Name | ZM 449829 | ||
| Synonyms | ZM449829; ZM-449829; JAK3 Inhibitor V; | ||
| SMILES | C=CC(C2=CC1=CC=CC=C1C=C2)=O | ||
| Chemical Name | |||
| Formula | C13H10O | M. Wt | 182.22 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | Potent, selective inhibitor of Janus tyrosine kinase 3 (JAK3) which binds competitively to the JAK3 ATP site. pIC50 values are 6.8, 5.0, 4.7, and < 5.0 for JAK3, EGFR, JAK1 and CDK4 respectively. Inhibits STAT-5 phosphorylation and T-cell proliferation. | ||
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