TMCB
| CAS No. | 905105-89-7 | Cat. No. | BCP27716 |
| Name | TMCB | ||
| Synonyms | |||
| Formula | C11H9Br4N3O2 | M. Wt | 534.83 |
| Description | TMCB is a dual-kinase inhibitor of both casein kinase 2 (CK2) and extracellular-signal-regulated kinase 8 (ERK8) (IC50 = 0.50 μM for both CK2 and ERK8). TMCB exhibits selectivity for CK2 over protein kinases normally susceptible to CK2 inhibitors (Ki = 0.25, 8.65, 11.90 and 15.25 μM for CK2, PIM1, DYRK1a and HIPK2, respectively). | ||
| Pathways | Cell Cycle/DNA Damage Wnt/Stem Cell MAPK Pathway | ||
| Targets | Casein Kinase MEK/ERK | ||
Structure
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