Upadacitinib hemihydrate
| CAS No. | 2050057-56-0 | Cat. No. | BCP41039 |
| Name | Upadacitinib hemihydrate | ||
| Synonyms | ABT-494 hemihydrate;ABT494 hemihydrate;ABT 494 hemihydrate; | ||
| Formula | C34H40F6N12O3 | M. Wt | 778.77 |
| Description | Upadacitinib, also known as ABT-494, is a potent and selective JAK inhibitors in development for rheumatoid arthritis. ABT-494 is approximately 74 fold selective for Jak1 over Jak2 in cellular assays dependent on specific, relevant cytokines. ABT-494 demonstrates efficacy in rat arthritis models. Preliminary evidence suggests that compared to tofacitinib, ABT-494 may spare Jak2 and Jak3 dependent signaling. | ||
| Related Products | 1607431-21-9（Upadacitinib tartrate） 1310726-60-3（Upadacitinib） | ||
| Pathways | Angiogenesis/Protein Tyrosine Kinase Jak/Stat Pathway Wnt/Stem Cell Epigenetics | ||
| Targets | JAK | ||
Structure
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