Upadacitinib
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CAS No. | 1310726-60-3 | Cat. No. | BCP19011 |
Related Products | 1607431-21-9(Upadacitinib tartrate) 2050057-56-0(Upadacitinib hemihydrate) | ||
Name | Upadacitinib | ||
Synonyms | ABT494;ABT-494;ABT 494; | ||
SMILES | O=C(N1C[C@@H](CC)[C@@H](C2=CN=C3C=NC(NC=C4)=C4N32)C1)NCC(F)(F)F | ||
Chemical Name | |||
Formula | C17H19F3N6O | M. Wt | 380.1572 |
Purity | 98% | Storage | Store at 4-8°C |
Description | Upadacitinib, also known as ABT-494, is a potent and selective JAK inhibitors in development for rheumatoid arthritis. ABT-494 is approximately 74 fold selective for Jak1 over Jak2 in cellular assays dependent on specific, relevant cytokines. ABT-494 demonstrates efficacy in rat arthritis models. Preliminary evidence suggests that compared to tofacitinib, ABT-494 may spare Jak2 and Jak3 dependent signaling. |
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