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Upadacitinib Chemical Structure

Upadacitinib

Data Sheet For research use only. Not for human use.
Cat. No. :BCP19011CAS No. :1310726-60-3Purity:98%
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  • Chemical Properties&Biological Activity
CAS No. 1310726-60-3 Cat. No. BCP19011
Related Products 1607431-21-9(Upadacitinib tartrate) 2050057-56-0(Upadacitinib hemihydrate)
Name Upadacitinib
Synonyms ABT494;ABT-494;ABT 494;
SMILES O=C(N1C[C@@H](CC)[C@@H](C2=CN=C3C=NC(NC=C4)=C4N32)C1)NCC(F)(F)F
Chemical Name
Formula C17H19F3N6O M. Wt 380.1572
Purity 98% Storage Store at 4-8°C
Description Upadacitinib, also known as ABT-494, is a potent and selective JAK inhibitors in development for rheumatoid arthritis. ABT-494 is approximately 74 fold selective for Jak1 over Jak2 in cellular assays dependent on specific, relevant cytokines. ABT-494 demonstrates efficacy in rat arthritis models. Preliminary evidence suggests that compared to tofacitinib, ABT-494 may spare Jak2 and Jak3 dependent signaling.
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