SRX3177
| CAS No. | 2241237-51-2 | Cat. No. | BCP48567 |
| Name | SRX3177 | ||
| Synonyms | SRX-3177; SRX 3177; | ||
| Formula | C31H32N6O4S | M. Wt | 584.69 |
| Description | SRX3177 is a triple inhibitor of CDK, PI3K, and BRD4, with IC50s of 33 nM (BRD4 BD1), 89 nM (BRD4 BD2), 79 nM (PI3Kα), 83 nM (PI3Kδ), 3.18 μM (PI3Kγ), <2.5 nM (CDK4), 3.3 nM (CDK6), respectively. SRX3177 exerts broad cytotoxic activity against cancer cells, but acts friendly with normal epithelial cells. | ||
| Pathways | Cell Cycle/DNA Damage PI3K/Akt/mTOR Epigenetics | ||
| Targets | Epigenetic Reader Domain PI3K CDK | ||
Structure
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